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Details on Person CYP8B1 12-hydroxylates 4CHOL7aOLONE

Class:IdReaction:192157
_displayNameCYP8B1 12-hydroxylates 4CHOL7aOLONE
_doReleaseTRUE
_timestamp2024-04-15 21:37:59
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:192125] sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference[DatabaseIdentifier:9907725] RHEA:46753
edited[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input[SimpleEntity:192136] 4CHOL7aOLONE [endoplasmic reticulum membrane]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:192101] Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns
[LiteratureReference:5602286] Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase
modified[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351776] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907727] D'Eustachio, Peter, 2024-04-15
nameCYP8B1 12-hydroxylates 4CHOL7aOLONE
7alpha-hydroxycholest-4-en-3-one + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
output[SimpleEntity:192195] 4CHOL7a,12aDONE [endoplasmic reticulum membrane]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360330] R-HSA-192157.3
summation[Summation:192122] Sterol 12alpha hydroxylase (CYP8B1), an enzyme associated wi...
(hasEvent)[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
[Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 [Homo sapiens]
(precedingEvent)[Reaction:192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786297] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v50:[addLiteratureReference, modifyText]
[_UpdateTracker:9910998] Update Tracker - [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - v89:[modifyText]
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No pathways have been reviewed or authored by CYP8B1 12-hydroxylates 4CHOL7aOLONE (192157)
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