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Details on Person CYP27A1 27-hydroxylates CHOL

Class:IdReaction:192123
_displayNameCYP27A1 27-hydroxylates CHOL
_doReleaseTRUE
_timestamp2026-04-29 20:05:01
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:192037] oxidoreductase activity, acting on NAD(P)H as acceptor of CYP27A1 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference[DatabaseIdentifier:9987900] RHEA:43837
edited[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input[SimpleEntity:193840] CHOL [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113533] O2 [mitochondrial matrix]
literatureReference[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
modified[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00
[InstanceEdit:193803] D'Eustachio, P, 2007-02-27 22:01:10
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:211789] Jassal, Bijay, 2008-02-08
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351778] Jassal, Bijay, 2008-05-28
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9987901] D'Eustachio, Peter, 2026-04-29
nameCYP27A1 27-hydroxylates CHOL
cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)
output[SimpleEntity:193846] 27OH-CHOL [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361102] R-HSA-192123.2
summation[Summation:192152] Cholesterol (CHOL), NADPH + H+, and O2 react to form 27-hydr...
(hasEvent)[Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(precedingEvent)[BlackBoxEvent:193812] Efflux of 27-hydroxycholesterol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786082] Update Tracker - [Reaction:192123] CYP27A1 27-hydroxylates CHOL - v50:[modifyText]
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No pathways have been reviewed or authored by CYP27A1 27-hydroxylates CHOL (192123)
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