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Details on Person 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one

Class:Id	Reaction:192097
_displayName	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
_doRelease	TRUE
_timestamp	2026-04-27 21:30:26
authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192106] steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD3B7 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input	[SimpleEntity:192114] 7 alpha-hydroxycholesterol [endoplasmic reticulum membrane] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:193374] Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease [LiteratureReference:193532] The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
modified	[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47 [InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
name	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one 7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH
output	[SimpleEntity:192136] 4CHOL7aOLONE [endoplasmic reticulum membrane] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:192051] CYP7A1 7-hydroxylates CHOL [Homo sapiens] [Reaction:5340195] NR1H4 binds DCA, CDCA, LCHA [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361899] R-HSA-192097.2
summation	[Summation:192135] 7alpha-hydroxycholesterol and NAD+ react to form 4-cholesten...
(hasEvent)	[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(precedingEvent)	[Reaction:192033] 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one [Homo sapiens] [Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE [Homo sapiens]
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