Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person CYP27A1, a mitochondrial matrix sterol hydroxylase, catalyse...
| Class:Id | Summation:192093 |
|---|---|
| _displayName | CYP27A1, a mitochondrial matrix sterol hydroxylase, catalyse... |
| _timestamp | 2014-06-20 12:06:34 |
| created | [InstanceEdit:191989] Jassal, Bijay, 2007-01-26 |
| modified | [InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33 [InstanceEdit:5602197] Jassal, Bijay, 2014-06-20 |
| text | CYP27A1, a mitochondrial matrix sterol hydroxylase, catalyses the 27-hydroxylation of side-chains of sterol intermediates (Cali et al. 1991). A specific reaction is the 27-hydroxylation of 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (5bCHOL3a,7a,12a-triol) to form 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol (5bCHOL3a,7a,12a, 27-tetrol) (Pikuleva et al. 1998). Defects in CYP27A1 can cause Cerebrotendinous xanthomatosis (CTX; MIM:213700), a rare sterol storage disorder characterised by progressive neurologic dysfunction, premature atherosclerosis and cataracts (Cali et al. 1991b). |
| (summation) | [Reaction:191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by CYP27A1, a mitochondrial matrix sterol hydroxylase, catalyse... (192093)
