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Details on Person 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

Class:Id	Reaction:192067
_displayName	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one
_doRelease	TRUE
_timestamp	2026-04-27 21:30:23
authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192006] alcohol dehydrogenase (NADP+) activity of AKR1D1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9987762] RHEA:46633
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input	[SimpleEntity:192195] 4CHOL7a,12aDONE [endoplasmic reticulum membrane] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:192039] Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme
modified	[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47 [InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
name	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)
output	[SimpleEntity:192064] 5beta-cholesten-7alpha, 12alpha-diol-3-one [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE [Homo sapiens] [Reaction:192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358639] R-HSA-192067.2
summation	[Summation:192052] 4-Cholesten-7alpha, 12alpha-diol-3-one and NADPH + H+ react ...
(hasEvent)	[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(precedingEvent)	[Reaction:192036] 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol [Homo sapiens]
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