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Details on Person CYP7B1 7-hydroxylates 25OH-CHOL

Class:IdReaction:192065
_displayNameCYP7B1 7-hydroxylates 25OH-CHOL
_doReleaseTRUE
_timestamp2024-04-15 21:37:53
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:192095] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference[DatabaseIdentifier:9907728] RHEA:24309
edited[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input[SimpleEntity:192148] 25OH-CHOL [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:191992] Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
modified[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:211789] Jassal, Bijay, 2008-02-08
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351776] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5340205] Jassal, Bijay, 2014-03-12
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:5674209] Jassal, Bijay, 2015-02-11
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907727] D'Eustachio, Peter, 2024-04-15
nameCYP7B1 7-hydroxylates 25OH-CHOL
25-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output[SimpleEntity:192184] CHOL3b,7a,25TRIOL [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:5340417] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358421] R-HSA-192065.4
summation[Summation:192156] 25-hydroxycholesterol (25OH-CHOL) is 7alpha-hydroxylated to ...
(hasEvent)[Pathway:192105] Synthesis of bile acids and bile salts [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(normalReaction)[FailedReaction:5602885] Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786260] Update Tracker - [Reaction:192065] CYP7B1 7-hydroxylates 25OH-CHOL - v50:[modifyText]
[_UpdateTracker:9786384] Update Tracker - [Reaction:192065] CYP7B1 7-hydroxylates 25OH-CHOL - v49:[addRegulator]
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No pathways have been reviewed or authored by CYP7B1 7-hydroxylates 25OH-CHOL (192065)
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