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Details on Person CYP46A1 24-hydroxylates CHOL

Class:IdReaction:192061
_displayNameCYP46A1 24-hydroxylates CHOL
_doReleaseTRUE
_timestamp2026-04-27 21:30:30
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:192143] cholesterol 24-hydroxylase activity of CYP46A1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference[DatabaseIdentifier:9907886] RHEA:22717
edited[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input[SimpleEntity:193384] CHOL [endoplasmic reticulum membrane]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:192035] Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain
[LiteratureReference:192002] cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
modified[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:211789] Jassal, Bijay, 2008-02-08
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351778] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907889] D'Eustachio, Peter, 2024-04-17
[InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
nameCYP46A1 24-hydroxylates CHOL
cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O
output[SimpleEntity:192060] 24OH-CHOL [endoplasmic reticulum membrane]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358225] R-HSA-192061.3
summation[Summation:191967] Cholesterol 24-hydroxylase (CYP46A1), an enzyme associated w...
(hasEvent)[Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(precedingEvent)[BlackBoxEvent:193776] Efflux of 24-hydroxycholesterol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786085] Update Tracker - [Reaction:192061] CYP46A1 24-hydroxylates CHOL - v50:[modifyText]
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No pathways have been reviewed or authored by CYP46A1 24-hydroxylates CHOL (192061)
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