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Details on Person CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol

Class:IdReaction:191999
_displayNameCYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol
_doReleaseTRUE
_timestamp2014-06-20 12:06:25
authored[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity[CatalystActivity:192037] oxidoreductase activity, acting on NAD(P)H as acceptor of CYP27A1 [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
edited[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input[SimpleEntity:192078] 5bCHOL3a,7a,12a-triol [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113533] O2 [mitochondrial matrix]
literatureReference[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
[LiteratureReference:193487] Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
[LiteratureReference:193375] Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
modified[InstanceEdit:192359] Jassal, B, 2007-01-31 12:07:53
[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:5602197] Jassal, Bijay, 2014-06-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol
5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol
5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
output[SimpleEntity:192201] 5bCHOL3a,7a,12a,27-tetrol [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358740] R-HSA-191999.2
summation[Summation:192093] CYP27A1, a mitochondrial matrix sterol hydroxylase, catalyse...
(hasEvent)[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(normalReaction)[FailedReaction:5602170] CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol [Homo sapiens]
(precedingEvent)[Reaction:192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786113] Update Tracker - [Reaction:191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol - v50:[modifyText]
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No pathways have been reviewed or authored by CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (191999)
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