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Details on Person Cholesterol is hydroxylated to 25-hydroxycholesterol

Class:Id	Reaction:191983
_displayName	Cholesterol is hydroxylated to 25-hydroxycholesterol
_doRelease	TRUE
_timestamp	2026-04-29 20:05:01
authored	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity	[CatalystActivity:192119] steroid hydroxylase activity of CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9987902] RHEA:46133
edited	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input	[SimpleEntity:176478] CHOL [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:192168] cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
modified	[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47 [InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987901] D'Eustachio, Peter, 2026-04-29
name	Cholesterol is hydroxylated to 25-hydroxycholesterol cholesterol + NADPH + O2 + H(+) => 25-hydroxycholesterol + NADP(+) + H2O
output	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:192148] 25OH-CHOL [cytosol]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361553] R-HSA-191983.2
summation	[Summation:192005] The microsomal enzyme cholesterol 25-hydroxylase is a member...
(hasEvent)	[Pathway:192105] Synthesis of bile acids and bile salts [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791960] Update Tracker - [Reaction:191983] Cholesterol is hydroxylated to 25-hydroxycholesterol - v24:[add_removeInput]
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No pathways have been reviewed or authored by Cholesterol is hydroxylated to 25-hydroxycholesterol (191983)