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Details on Person 27-hydroxycholesterol is 7alpha-hydroxylated

Class:IdReaction:191972
_displayName27-hydroxycholesterol is 7alpha-hydroxylated
_doReleaseTRUE
_timestamp2015-02-11 13:13:10
authored[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity[CatalystActivity:192095] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
edited[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input[SimpleEntity:176617] 27HCHOL [endoplasmic reticulum membrane]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:191992] Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
modified[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47
[InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00
[InstanceEdit:193803] D'Eustachio, P, 2007-02-27 22:01:10
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5340205] Jassal, Bijay, 2014-03-12
[InstanceEdit:5674209] Jassal, Bijay, 2015-02-11
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name27-hydroxycholesterol is 7alpha-hydroxylated
27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
output[SimpleEntity:192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:5340418] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate2007-05-15
reviewed[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361030] R-HSA-191972.3
summation[Summation:193810] 27-hydroxycholesterol, NADPH + H+, and O2 react to form chol...
(hasEvent)[Pathway:193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol [Homo sapiens]
(precedingEvent)[Reaction:193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786376] Update Tracker - [Reaction:191972] 27-hydroxycholesterol is 7alpha-hydroxylated - v49:[addRegulator]
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