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Details on Person MVD decarboxylates MVA5PP to IPPP

Class:Id	Reaction:191414
_displayName	MVD decarboxylates MVA5PP to IPPP
_doRelease	TRUE
_timestamp	2025-11-04 21:55:48
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191297] diphosphomevalonate decarboxylase activity of MVD dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9937307] RHEA:23733
edited	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
input	[SimpleEntity:191403] MVA5PP [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9971192] D'Eustachio, Peter, 2025-11-04
literatureReference	[LiteratureReference:191310] Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase
modified	[InstanceEdit:191585] D'Eustachio, P, 2007-01-20 20:43:27 [InstanceEdit:191757] Jassal, B, 2007-01-24 15:17:59 [InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:4419988] Jassal, B, 2013-08-29 [InstanceEdit:4420217] Jassal, B, 2013-08-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10 [InstanceEdit:9971186] D'Eustachio, Peter, 2025-11-04 [InstanceEdit:9971191] D'Eustachio, Peter, 2025-11-04 [InstanceEdit:9971195] D'Eustachio, Peter, 2025-11-04
name	MVD decarboxylates MVA5PP to IPPP (R)-5-diphosphomevalonate + ATP => isopentenyl diphosphate + ADP + phosphate + CO2
output	[SimpleEntity:191362] IPPP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:191422] Mevalonate-5-phosphate is further phosphorylated [Homo sapiens] [Reaction:191380] Mevalonate is phosphorylated to mevalonate-5-phosphate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07 [InstanceEdit:9971194] D'Eustachio, Peter, 2025-11-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359374] R-HSA-191414.5
structureModified	[InstanceEdit:9971186] D'Eustachio, Peter, 2025-11-04
summation	[Summation:191378] Mevalonate pyrophosphate decarboxylase (MPD) decarboxylates ...
(hasEvent)	[Pathway:446199] Synthesis of dolichyl-phosphate [Homo sapiens] [Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191303] FDPS dimer transfers IPPP to GPP [Homo sapiens] [Reaction:191322] FDPS dimer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate [Homo sapiens] [Reaction:4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP [Homo sapiens] [Reaction:9717830] GGPS1 hexamer transfers IPPP to GPP [Homo sapiens] [Reaction:9717834] GGPS1 hexamer transfers IPPP to DMAPP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786992] Update Tracker - [Reaction:191414] MVD decarboxylates MVA5PP to IPPP - v46:[modifyText] [_UpdateTracker:9971938] Update Tracker - [Reaction:191414] MVD decarboxylates MVA5PP to IPPP - v95:[addOutput]
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