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Details on Person Two FAPP molecules dimerize to form presqualene diphosphate

Class:Id	Reaction:191405
_displayName	Two FAPP molecules dimerize to form presqualene diphosphate
_doRelease	TRUE
_timestamp	2025-10-22 21:36:32
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191305] squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9945097] RHEA:22673
input	[SimpleEntity:191385] FAPP [cytosol] [SimpleEntity:191385] FAPP [cytosol]
literatureReference	[LiteratureReference:201364] Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
modified	[InstanceEdit:191760] Jassal, B, 2007-01-24 15:19:26 [InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:201360] D'Eustachio, P, 2007-08-06 20:39:37 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9717837] Jassal, Bijay, 2021-03-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10 [InstanceEdit:9969571] D'Eustachio, Peter, 2025-10-22
name	Two FAPP molecules dimerize to form presqualene diphosphate 2 (2E,6E)-farnesyl diphosphate => presqualene diphosphate + diphosphate
output	[SimpleEntity:111294] PPi [cytosol] [SimpleEntity:191265] PSQPP [cytosol]
precedingEvent	[Reaction:191303] FDPS dimer transfers IPPP to GPP [Homo sapiens] [Reaction:191322] FDPS dimer transfers IPPP to DMAPP [Homo sapiens] [Reaction:9717834] GGPS1 hexamer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:9717830] GGPS1 hexamer transfers IPPP to GPP [Homo sapiens] [Reaction:9717834] GGPS1 hexamer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191322] FDPS dimer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361461] R-HSA-191405.5
summation	[Summation:191347] Farnesyl diphosphate farnesyltransferase (FDFT; squalene syn...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191402] Reduction of presqualene diphosphate to form squalene [Homo sapiens] [Reaction:8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792364] Update Tracker - [Reaction:191405] Two FPP molecules dimerize to form presqualene diphosphate - v22:[addLiteratureReference, modifyText] [_UpdateTracker:9971886] Update Tracker - [Reaction:191405] Two FAPP molecules dimerize to form presqualene diphosphate - v95:[modifyText]
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