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Details on Person Reduction of presqualene diphosphate to form squalene

Class:IdReaction:191402
_displayNameReduction of presqualene diphosphate to form squalene
_doReleaseTRUE
_timestamp2025-04-10 22:22:44
authored[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity[CatalystActivity:191305] squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference[DatabaseIdentifier:9945081] RHEA:22233
input[SimpleEntity:191265] PSQPP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
literatureReference[LiteratureReference:201364] Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
modified[InstanceEdit:191760] Jassal, B, 2007-01-24 15:19:26
[InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:201360] D'Eustachio, P, 2007-08-06 20:39:37
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10
nameReduction of presqualene diphosphate to form squalene
presqualene diphosphate + NADPH + H(+) => squalene + diphosphate + NADP(+)
output[SimpleEntity:191269] SQNE [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:111294] PPi [cytosol]
precedingEvent
releaseDate2007-02-20
reviewed[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359634] R-HSA-191402.3
summation[Summation:191274] In the second step of squalene formation from farnesyl dipho...
(hasEvent)[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:191299] Squalene is oxidized to its epoxide [Homo sapiens]
(updatedInstance)[_UpdateTracker:9792260] Update Tracker - [Reaction:191402] Reduction of presqualene diphosphate to form squalene - v22:[addLiteratureReference, modifyText]
[_UpdateTracker:9971895] Update Tracker - [Reaction:191402] Reduction of presqualene diphosphate to form squalene - v95:[modifyText]
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