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Details on Person Mevalonate is phosphorylated to mevalonate-5-phosphate

Class:Id	Reaction:191380
_displayName	Mevalonate is phosphorylated to mevalonate-5-phosphate
_doRelease	TRUE
_timestamp	2025-10-23 21:30:44
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191389] mevalonate kinase activity of MVK dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9945086] RHEA:17066
input	[SimpleEntity:191424] MVA [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9947454] D'Eustachio, Peter, 2025-05-05
literatureReference	[LiteratureReference:191379] Mevalonate kinase is a cytosolic enzyme in humans [LiteratureReference:191586] Biochemical and genetic aspects of mevalonate kinase and its deficiency [LiteratureReference:191412] Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria
modified	[InstanceEdit:191585] D'Eustachio, P, 2007-01-20 20:43:27 [InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07 [InstanceEdit:191757] Jassal, B, 2007-01-24 15:17:59 [InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10 [InstanceEdit:9947453] D'Eustachio, Peter, 2025-05-05 [InstanceEdit:9953268] D'Eustachio, Peter, 2025-05-30 [InstanceEdit:9969889] D'Eustachio, Peter, 2025-10-23
name	Mevalonate is phosphorylated to mevalonate-5-phosphate (R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)
output	[SimpleEntity:191296] MVA5P [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA [Homo sapiens] [Reaction:191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07 [InstanceEdit:9953269] Hill, David P, 2025-05-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360160] R-HSA-191380.4
structureModified	[InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10
summation	[Summation:191342] Cytosolic mevalonate kinase (MK) catalyzes the phosphorylati...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191422] Mevalonate-5-phosphate is further phosphorylated [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953619] Update Tracker - [Reaction:191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - v93:[removeOutput] [_UpdateTracker:9971854] Update Tracker - [Reaction:191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - v95:[modifyText, removeLiteratureReference]
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