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Details on Person FDPS dimer transfers IPPP to GPP

Class:Id	Reaction:191303
_displayName	FDPS dimer transfers IPPP to GPP
_doRelease	TRUE
_timestamp	2025-06-06 20:51:47
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:981559] (2E,6E)-farnesyl diphosphate synthase activity of holo-FDPS dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9945085] RHEA:19362
edited	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
input	[SimpleEntity:191409] GPP [cytosol] [SimpleEntity:191362] IPPP [cytosol]
literatureReference	[LiteratureReference:191398] Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. [LiteratureReference:191275] Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression [LiteratureReference:981558] The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
modified	[InstanceEdit:191759] Jassal, B, 2007-01-24 15:18:55 [InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:981563] Jassal, B, 2010-10-25 [InstanceEdit:9717837] Jassal, Bijay, 2021-03-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10 [InstanceEdit:9954123] D'Eustachio, Peter, 2025-06-06
name	FDPS dimer transfers IPPP to GPP isopentenyl diphosphate + (2E)-geranyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
output	[SimpleEntity:191385] FAPP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:191322] FDPS dimer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:9717834] GGPS1 hexamer transfers IPPP to DMAPP [Homo sapiens] [Reaction:191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:191422] Mevalonate-5-phosphate is further phosphorylated [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359179] R-HSA-191303.5
summation	[Summation:191267] Further condensation of an isopentenyl pyrophosphate (IPPP) ...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191405] Two FAPP molecules dimerize to form presqualene diphosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776251] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v77:[modifyText] [_UpdateTracker:9790174] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v35:[addLiteratureReference, add_removeCatalystActivity, modifyText] [_UpdateTracker:9971933] Update Tracker - [Reaction:191303] FDPS dimer transfers IPPP to GPP - v95:[modifyText]
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