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Details on Person Squalene is oxidized to its epoxide

Class:Id	Reaction:191299
_displayName	Squalene is oxidized to its epoxide
_doRelease	TRUE
_timestamp	2025-04-10 22:22:47
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191350] squalene monooxygenase activity of SQLE:FAD [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9945093] RHEA:25282
input	[SimpleEntity:191269] SQNE [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:191271] Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
modified	[InstanceEdit:191585] D'Eustachio, P, 2007-01-20 20:43:27 [InstanceEdit:191760] Jassal, B, 2007-01-24 15:19:26 [InstanceEdit:192362] D'Eustachio, P, 2007-01-31 15:17:45 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10
name	Squalene is oxidized to its epoxide squalene + reduced (NADPH--hemoprotein reductase) + O2 = (S)-2,3-epoxysqualene + oxidized (NADPH--hemoprotein reductase) + H2O + H(+)
output	[SimpleEntity:191309] SQOX [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:191402] Reduction of presqualene diphosphate to form squalene [Homo sapiens] [Reaction:191405] Two FAPP molecules dimerize to form presqualene diphosphate [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361382] R-HSA-191299.3
summation	[Summation:191284] Squalene monooxygenase (squalene epoxidase, SE) is located o...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191366] Squalene 2,3-epoxide cyclizes, forming lanosterol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971903] Update Tracker - [Reaction:191299] Squalene is oxidized to its epoxide - v95:[modifyText]
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