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Details on Person NOTCH1 gene transcription

Class:IdBlackBoxEvent:1912416
_displayNameNOTCH1 gene transcription
_doReleaseTRUE
_timestamp2016-03-18 15:00:33
authored[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
edited[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
[InstanceEdit:2251519] D'Eustachio, P, 2012-05-15
inferredFrom
input[EntityWithAccessionedSequence:1911481] NOTCH1 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
[LiteratureReference:2105564] Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
[LiteratureReference:1485609] Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
[LiteratureReference:2152329] Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases
[LiteratureReference:2152376] Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
[LiteratureReference:2247526] p53 regulates thymic Notch1 activation
[LiteratureReference:2251506] Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells
[LiteratureReference:2251499] Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart
[LiteratureReference:2251500] Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
[LiteratureReference:2251511] Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes
[LiteratureReference:2251514] DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells
[LiteratureReference:2247540] Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
[LiteratureReference:2247943] Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
modified[InstanceEdit:2025691] Orlic-Milacic, M, 2011-12-14
[InstanceEdit:2032350] Orlic-Milacic, M, 2012-01-06
[InstanceEdit:2105575] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13
[InstanceEdit:2152337] Orlic-Milacic, M, 2012-02-27
[InstanceEdit:2152390] Orlic-Milacic, M, 2012-02-27
[InstanceEdit:2251517] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:2251532] Orlic-Milacic, M, 2012-05-16
[InstanceEdit:2252622] Orlic-Milacic, M, 2012-05-17
[InstanceEdit:2252634] D'Eustachio, P, 2012-05-18
[InstanceEdit:2252635] D'Eustachio, P, 2012-05-18
[InstanceEdit:4395233] Orlic-Milacic, M, 2013-08-22
[InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH1 gene transcription
output[EntityWithAccessionedSequence:1606559] NOTCH1 mRNA [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:2247933] Positive gene expression regulation by 'NOTCH1 Coactivator Complex [nucleoplasm]'
[PositiveGeneExpressionRegulation:2247947] Positive gene expression regulation by 'CCND1:CREBBP:NOTCH1 Gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:2248827] Positive gene expression regulation by 'E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm]'
regulationReference[RegulationReference:9641408] Positive gene expression regulation by 'CCND1:CREBBP:NOTCH1 Gene [nucleoplasm]' Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
[RegulationReference:9641935] Positive gene expression regulation by 'NOTCH1 Coactivator Complex [nucleoplasm]' Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
[RegulationReference:9642722] Positive gene expression regulation by 'E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm]' Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
releaseDate2012-03-13
reviewed[InstanceEdit:2121207] Haw, R, 2012-02-06
[InstanceEdit:2252619] Haw, R, 2012-05-17
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2252620] Egan, SE, Orlic-Milacic, M, 2012-05-14
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2158056] R-HSA-1912416.5
summation[Summation:2025692] NOTCH1 was cloned as a chromosome 9 gene involved in translo...
(hasEvent)[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
(precedingEvent)[Reaction:1606561] MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA [Homo sapiens]
[Reaction:1606682] MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA [Homo sapiens]
[Reaction:1912363] MIR200B/C microRNAs bind NOTCH1 mRNA [Homo sapiens]
[BlackBoxEvent:1912412] NOTCH1 mRNA translation controlled by miRNAs [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787174] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v46:[add_removeRegulator, modifyText]
[_UpdateTracker:9788512] Update Tracker - [BlackBoxEvent:1912416] NOTCH1 gene transcription - v41:[addLiteratureReference, addRegulator, modifyText]
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No pathways have been reviewed or authored by NOTCH1 gene transcription (1912416)
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