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Details on Person NOTCH4 mRNA translation controlled by miRNAs

Class:IdBlackBoxEvent:1912410
_displayNameNOTCH4 mRNA translation controlled by miRNAs
_doReleaseTRUE
_timestamp2024-11-08 15:09:25
authored[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:1912405] Orlic-Milacic, M, 2011-11-01
edited[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2121209] May, B, 2012-02-09
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
[InstanceEdit:1609686] Jupe, S, 2011-09-27
[InstanceEdit:2121211] Gillespie, ME, 2012-02-09
goBiologicalProcess[GO_BiologicalProcess:161121] miRNA-mediated gene silencing by inhibition of translation
input[EntityWithAccessionedSequence:1911475] NOTCH4 mRNA [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1890316] Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
[LiteratureReference:1890304] Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
modified[InstanceEdit:2023191] Orlic-Milacic, M, 2011-12-06
[InstanceEdit:2029535] Orlic-Milacic, M, 2012-01-04
[InstanceEdit:2032336] Orlic-Milacic, M, 2012-01-06
[InstanceEdit:2105667] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2106575] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13
[InstanceEdit:9605464] Orlic-Milacic, Marija, 2018-04-11
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9927655] Orlic-Milacic, Marija, 2024-11-08
nameNOTCH4 mRNA translation controlled by miRNAs
negativePrecedingEvent[NegativePrecedingEvent:9927652] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
[NegativePrecedingEvent:9927653] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1
output[EntityWithAccessionedSequence:157121] Pre-NOTCH4 [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:1980092] Negative regulation by 'NOTCH4 mRNA:miR-181C RISC [cytosol]'
[NegativeRegulation:1980094] Negative regulation by 'NOTCH4 mRNA:miR-302A RISC [cytosol]'
releaseDate2012-03-13
reviewed[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2158008] R-HSA-1912410.4
summation[Summation:2029547] Translation of NOTCH4 mRNA is negatively regulated by miR-18...
(hasEvent)[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
(precedingEvent)[Reaction:1912349] Fucosylation of Pre-NOTCH by POFUT1 [Homo sapiens]
[BlackBoxEvent:1912414] Pre-NOTCH translocates to endoplasmic reticulum [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH4 mRNA translation controlled by miRNAs (1912410)
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