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Details on Person Fringe-modified Pre-NOTCH is cleaved by FURIN

Class:Id	Reaction:1912372
_displayName	Fringe-modified Pre-NOTCH is cleaved by FURIN
_doRelease	TRUE
_timestamp	2012-03-01 11:24:43
authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:1912373] Orlic-Milacic, M, 2011-11-01
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
input	[CandidateSet:1911509] Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH [Golgi membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch [LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [LiteratureReference:2153479] Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins
modified	[InstanceEdit:2023188] Orlic-Milacic, M, 2011-12-06 [InstanceEdit:2043103] Orlic-Milacic, M, 2012-01-10 [InstanceEdit:2046122] Orlic-Milacic, M, 2012-01-11 [InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13 [InstanceEdit:2121218] Orlic-Milacic, M, 2012-02-13 [InstanceEdit:2153480] Orlic-Milacic, M, 2012-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fringe-modified Pre-NOTCH is cleaved by FURIN
output	[CandidateSet:1911547] FRINGE-modified NOTCH [Golgi membrane] [Homo sapiens]
precedingEvent	[Reaction:1912378] Sialylation of Pre-NOTCH [Homo sapiens] [Reaction:1912352] Galactosylation of Pre-NOTCH [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158197] R-HSA-1912372.2
summation	[Summation:2043101] Cleavage of fringe-modified NOTCH by FURIN has not been exam...
(hasEvent)	[Pathway:1912420] Pre-NOTCH Processing in Golgi [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1912379] Transport of fringe-modified NOTCH to plasma membrane [Homo sapiens]
(replacementInstances)	[_Deleted:5694730] Deletion of instance: 156994 [_Deleted:5694734] Deletion of instance: 157131 [_Deleted:5694737] Deletion of instance: 157042 [_Deleted:5694740] Deletion of instance: 157013
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No pathways have been reviewed or authored by Fringe-modified Pre-NOTCH is cleaved by FURIN (1912372)