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Details on Person MIR200B/C microRNAs bind NOTCH1 mRNA

Class:Id	Reaction:1912363
_displayName	MIR200B/C microRNAs bind NOTCH1 mRNA
_doRelease	TRUE
_timestamp	2024-11-08 15:09:17
authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1912365] Orlic-Milacic, M, 2011-11-01
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121209] May, B, 2012-02-09 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:1609686] Jupe, S, 2011-09-27 [InstanceEdit:2121211] Gillespie, ME, 2012-02-09
input	[EntityWithAccessionedSequence:1606559] NOTCH1 mRNA [cytosol] [Homo sapiens] [DefinedSet:1614237] miR-200B/C RISC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1888217] Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
modified	[InstanceEdit:1985680] Orlic-Milacic, M, 2011-11-11 [InstanceEdit:2023189] Orlic-Milacic, M, 2011-12-06 [InstanceEdit:2029532] Orlic-Milacic, M, 2012-01-04 [InstanceEdit:2032325] Orlic-Milacic, M, 2012-01-06 [InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9927655] Orlic-Milacic, Marija, 2024-11-08
name	MIR200B/C microRNAs bind NOTCH1 mRNA
negativePrecedingEvent	[NegativePrecedingEvent:9927648] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
output	[Complex:1911483] NOTCH1 mRNA:miR-200B/C RISC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1912416] NOTCH1 gene transcription [Homo sapiens] [Reaction:4395227] CCND1:CREBBP binds NOTCH1 promoter [Homo sapiens] [Reaction:4395231] E2F1/3:DP1/2 binds NOTCH1 promoter [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158100] R-HSA-1912363.3
summation	[Summation:1852625] Translation of NOTCH1 mRNA is inhibited by microRNAs miR-200...
(hasEvent)	[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
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No pathways have been reviewed or authored by MIR200B/C microRNAs bind NOTCH1 mRNA (1912363)