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Details on Person Fucosylation of Pre-NOTCH by POFUT1

Class:Id	Reaction:1912349
_displayName	Fucosylation of Pre-NOTCH by POFUT1
_doRelease	TRUE
_timestamp	2012-03-01 11:22:53
authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:1464800] peptide-O-fucosyltransferase activity of POFUT1 [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1912350] Orlic-Milacic, M, 2011-11-01
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
inferredFrom	[Reaction:1986584] Fucosylation of Pre-Notch by POFUT1 [Cricetulus griseus]
input	[SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [SimpleEntity:1463452] GDP-Fuc [endoplasmic reticulum lumen] [DefinedSet:1464801] Pre-NOTCH [endoplasmic reticulum membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1602200] Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions [LiteratureReference:1602192] Roles of Pofut1 and O-fucose in mammalian Notch signaling [LiteratureReference:1602208] Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase [LiteratureReference:1984028] Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region [LiteratureReference:2152397] Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
modified	[InstanceEdit:1985677] Orlic-Milacic, M, 2011-11-11 [InstanceEdit:1986585] Orlic-Milacic, M, 2011-11-11 [InstanceEdit:2023188] Orlic-Milacic, M, 2011-12-06 [InstanceEdit:2105679] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2106575] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13 [InstanceEdit:2152398] Orlic-Milacic, M, 2012-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fucosylation of Pre-NOTCH by POFUT1
output	[CandidateSet:1911414] Fuc-Pre-NOTCH [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen] [SimpleEntity:1467290] GDP [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:1912412] NOTCH1 mRNA translation controlled by miRNAs [Homo sapiens] [BlackBoxEvent:1912416] NOTCH1 gene transcription [Homo sapiens] [BlackBoxEvent:1912413] NOTCH2 mRNA translation controlled by miRNAs [Homo sapiens] [BlackBoxEvent:1912407] NOTCH2 gene transcription [Homo sapiens] [BlackBoxEvent:1912409] NOTCH3 mRNA translation controlled by miRNAs [Homo sapiens] [BlackBoxEvent:1912415] NOTCH3 gene transcription [Homo sapiens] [BlackBoxEvent:1912410] NOTCH4 mRNA translation controlled by miRNAs [Homo sapiens] [BlackBoxEvent:1912401] NOTCH4 gene transcription [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158124] R-HSA-1912349.2
summation	[Summation:1499949] In the endoplasmic reticulum, NOTCH receptor precursors are ...
(hasEvent)	[Pathway:1912399] Pre-NOTCH Processing in the Endoplasmic Reticulum [Homo sapiens]
(precedingEvent)	[Reaction:1912353] Glucosylation of Pre-NOTCH by POGLUT1 [Homo sapiens]
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No pathways have been reviewed or authored by Fucosylation of Pre-NOTCH by POFUT1 (1912349)