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Details on Person Hemi-channels appear to play a role in isosmotic cell volum...

Class:IdSummation:190811
_displayNameHemi-channels appear to play a role in isosmotic cell volum...
_timestamp2007-02-02 20:14:06
created[InstanceEdit:190826] Matthews, L, 2007-01-09 12:52:19
literatureReference[LiteratureReference:190813] Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation.
[LiteratureReference:190862] Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
[LiteratureReference:190726] Connexin-43 hemichannels opened by metabolic inhibition
[LiteratureReference:190759] Differential connexin expression, gap junction intercellular coupling, and hemichannel formation in NT2/D1 human neural progenitors and terminally differentiated hNT neurons
[LiteratureReference:190853] Structural organization of gap junctions as revealed by freeze-fracture and SDS fracture-labeling
[LiteratureReference:190729] Dispersed and aggregated gap junction channels identified by immunogold labeling of freeze-fractured membranes
[LiteratureReference:190728] Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells
[LiteratureReference:190858] Multicolor and electron microscopic imaging of connexin trafficking
modified[InstanceEdit:190933] Matthews, L, 2007-01-11 09:24:16
[InstanceEdit:192393] D'Eustachio, P, 2007-02-02 20:13:56
textHemi-channels appear to play a role in isosmotic cell volume regulation (Quist et al., 2000), in apoptosis regulation (Contreras et al. 2002; John et al. 1999), and in the differentiation of different cell types (Boucher and Bennett 2003). Individual connexons have been observed dispersed around gap junction plaques. This observation suggests that there is a pool of connexons dispersed in the plasma membrane which can migrate to gap junction plaques (Benedetti et al. 2000; Hulser et al. 1997; Lauf et al. 2002; Gaietta et al. 2002).
(summation)[Reaction:190877] Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels [Homo sapiens]
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