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Details on Person Autocatalytic phosphorylation of FGFR1c

Class:IdReaction:190429
_displayNameAutocatalytic phosphorylation of FGFR1c
_doReleaseTRUE
_timestamp2016-11-10 00:55:20
authored[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity[CatalystActivity:190431] protein tyrosine kinase activity of FGFR1c homodimer bound to FGF [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:190433] de Bono, B, 2007-01-02 16:43:07
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:190233] FGFR1c homodimer bound to FGF [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:201396] Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
[LiteratureReference:190962] Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
[LiteratureReference:443277] Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
[LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
[LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
modified[InstanceEdit:191579] de Bono, B, 2007-01-20 18:45:32
[InstanceEdit:192405] D'Eustachio, P, 2007-02-02 20:38:51
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:192611] D'Eustachio, P, 2007-02-06 23:16:07
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:201391] D'Eustachio, P, 2007-08-07 15:07:03
[InstanceEdit:1268166] Rothfels, K, 2011-05-09
[InstanceEdit:1315473] Rothfels, K, 2011-05-31
[InstanceEdit:1583039] Rothfels, K, 2011-09-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR1c
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:190425] Activated FGFR1c homodimer [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2006-04-24
reviewed[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360119] R-HSA-190429.3
summation[Summation:191577] Studies have mapped 8 tyrosine residues in the cytoplasmic d...
(hasEvent)[Pathway:190373] FGFR1c ligand binding and activation [Homo sapiens]
(normalReaction)[Reaction:2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers [Homo sapiens]
(precedingEvent)[Reaction:190351] FGFR binds FRS2 [Homo sapiens]
[Reaction:190391] SHC binds activated FGFR [Homo sapiens]
[Reaction:5654167] Activated FGFR1 binds PLCG1 [Homo sapiens]
[Reaction:5654569] Activated FGFR1 binds FRS2 [Homo sapiens]
[Reaction:5654571] Activated FGFR1 binds FRS3 [Homo sapiens]
[Reaction:5654573] Activated FGFR1 binds SHC1 [Homo sapiens]
[Reaction:5656064] Activated FGFR1 binds FLRT1,2,3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789541] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v37:[addLiteratureReference, modifyText]
[_UpdateTracker:9792232] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v22:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by Autocatalytic phosphorylation of FGFR1c (190429)
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