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Details on Person Autocatalytic phosphorylation of FGFR1b

Class:IdReaction:190427
_displayNameAutocatalytic phosphorylation of FGFR1b
_doReleaseTRUE
_timestamp2016-11-10 00:55:00
authored[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity[CatalystActivity:190428] protein tyrosine kinase activity of FGFR1b homodimer bound to FGF [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created[InstanceEdit:190433] de Bono, B, 2007-01-02 16:43:07
input[Complex:190226] FGFR1b homodimer bound to FGF [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
[LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
[LiteratureReference:191025] A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
[LiteratureReference:443277] Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
modified[InstanceEdit:190940] de Bono, B, 2007-01-11 09:51:46
[InstanceEdit:190946] de Bono, B, 2007-01-11 10:20:17
[InstanceEdit:191064] de Bono, B, 2007-01-13 13:05:19
[InstanceEdit:191576] de Bono, B, 2007-01-20 18:41:10
[InstanceEdit:192405] D'Eustachio, P, 2007-02-02 20:38:51
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:192611] D'Eustachio, P, 2007-02-06 23:16:07
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:1315472] Rothfels, K, 2011-05-31
[InstanceEdit:1583038] Rothfels, K, 2011-09-07
[InstanceEdit:2008175] Rothfels, K, 2011-11-21
[InstanceEdit:5656343] Rothfels, Karen, 2014-12-11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR1b
output[Complex:190430] Activated FGFR1b homodimer [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2007-02-28
reviewed[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361466] R-HSA-190427.3
summation[Summation:191577] Studies have mapped 8 tyrosine residues in the cytoplasmic d...
(hasEvent)[Pathway:190370] FGFR1b ligand binding and activation [Homo sapiens]
(precedingEvent)[Reaction:190351] FGFR binds FRS2 [Homo sapiens]
[Reaction:190391] SHC binds activated FGFR [Homo sapiens]
[Reaction:5654167] Activated FGFR1 binds PLCG1 [Homo sapiens]
[Reaction:5654569] Activated FGFR1 binds FRS2 [Homo sapiens]
[Reaction:5654571] Activated FGFR1 binds FRS3 [Homo sapiens]
[Reaction:5654573] Activated FGFR1 binds SHC1 [Homo sapiens]
[Reaction:5656064] Activated FGFR1 binds FLRT1,2,3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789890] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v37:[addLiteratureReference, modifyText]
[_UpdateTracker:9792365] Update Tracker - [Reaction:190427] Autocatalytic phosphorylation of FGFR1b - v22:[modifyText]
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No pathways have been reviewed or authored by Autocatalytic phosphorylation of FGFR1b (190427)
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