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Details on Person FGFR1c binds to Klotho-bound FGF23

Class:IdReaction:190268
_displayNameFGFR1c binds to Klotho-bound FGF23
_doReleaseTRUE
_timestamp2016-11-10 00:54:23
authored[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:190267] de Bono, B, 2006-12-18 16:14:42
input[Complex:190208] Klotho bound to FGF23 [plasma membrane] [Homo sapiens]
[SimpleEntity:190915] HS [extracellular region]
[Complex:190208] Klotho bound to FGF23 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:190251] Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
[LiteratureReference:190266] Klotho converts canonical FGF receptor into a specific receptor for FGF23
modified[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
[InstanceEdit:191576] de Bono, B, 2007-01-20 18:41:10
[InstanceEdit:192405] D'Eustachio, P, 2007-02-02 20:38:51
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:192611] D'Eustachio, P, 2007-02-06 23:16:07
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:194326] de Bono, B, 2007-03-13 15:50:27
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1268175] Rothfels, K, 2011-05-09
[InstanceEdit:1583054] Rothfels, K, 2011-09-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFGFR1c binds to Klotho-bound FGF23
output[Complex:190218] FGF23 bound to Klotho and FGFR1c [plasma membrane] [Homo sapiens]
regulatedBy[Requirement:190319] Requirement by 'HS [extracellular region]'
releaseDate2007-02-28
reviewed[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358226] R-HSA-190268.4
summation[Summation:191578] In this reaction, FGF receptor in the plasma membrane binds ...
(hasEvent)[Pathway:190374] FGFR1c and Klotho ligand binding and activation [Homo sapiens]
(precedingEvent)[Reaction:191062] Autocatalytic phosphorylation of Klotho-bound FGFR1c [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788977] Update Tracker - [Reaction:190268] FGFR1c binds to Klotho-bound FGF23 - v39:[add_removeRegulator]
[_UpdateTracker:9789621] Update Tracker - [Reaction:190268] FGFR1c binds to Klotho-bound FGF23 - v37:[add_removeInput, removeRegulator]
[_UpdateTracker:9842272] Update Tracker - [Reaction:190268] FGFR1c binds to Klotho-bound FGF23 - v86:[modifyText]
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