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Details on Person FGFR1c binds to FGF

Class:IdReaction:190256
_displayNameFGFR1c binds to FGF
_doReleaseTRUE
_timestamp2023-08-21 15:33:51
authored[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:190255] de Bono, B, 2006-12-18 15:58:02
input[DefinedSet:189953] FGFR1c-binding FGFs [extracellular region] [Homo sapiens]
[DefinedSet:189953] FGFR1c-binding FGFs [extracellular region] [Homo sapiens]
[SimpleEntity:190915] HS [extracellular region]
[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:189897] FGFR1c [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9842182] Orlic-Milacic, Marija, 2023-08-21
literatureReference[LiteratureReference:190251] Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
[LiteratureReference:191519] Structural basis for fibroblast growth factor receptor activation
modified[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
[InstanceEdit:191579] de Bono, B, 2007-01-20 18:45:32
[InstanceEdit:192405] D'Eustachio, P, 2007-02-02 20:38:51
[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:192611] D'Eustachio, P, 2007-02-06 23:16:07
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1235034] May, B, 2011-03-20
[InstanceEdit:1268174] Rothfels, K, 2011-05-09
[InstanceEdit:1308008] Rothfels, K, 2011-05-30
[InstanceEdit:1583053] Rothfels, K, 2011-09-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
[InstanceEdit:9840935] Tiwari, Krishna, 2023-08-01
[InstanceEdit:9842183] Orlic-Milacic, Marija, 2023-08-21
nameFGFR1c binds to FGF
output[Complex:190233] FGFR1c homodimer bound to FGF [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[Requirement:190311] Requirement by 'HS [extracellular region]'
[NegativeRegulation:5654431] Negative regulation by 'FGFR1c:KAL1 [plasma membrane]'
[PositiveRegulation:5654433] Positive regulation by 'KAL1:HS [extracellular region]'
[PositiveRegulation:9839338] Positive regulation by 'FGF2:TGFBR3:GIPC1'
regulationReference[RegulationReference:9840936] Positive regulation by 'FGF2:TGFBR3:GIPC1' Binding of two growth factor families to separate domains of the proteoglycan betaglycan
releaseDate2007-02-28
reviewed[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:1493881] Rothfels, K, 2011-08-16
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359243] R-HSA-190256.5
structureModified[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
summation[Summation:191578] In this reaction, FGF receptor in the plasma membrane binds ...
(hasEvent)[Pathway:190373] FGFR1c ligand binding and activation [Homo sapiens]
(normalReaction)[Reaction:2023451] FGFR1c P252X mutants bind ligand with enhanced affinity [Homo sapiens]
(precedingEvent)[Reaction:190429] Autocatalytic phosphorylation of FGFR1c [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785332] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v52:[addRegulator]
[_UpdateTracker:9789014] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v39:[add_removeRegulator]
[_UpdateTracker:9789711] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v37:[addLiteratureReference, add_removeInput, removeRegulator]
[_UpdateTracker:9842283] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v86:[addRegulator, modifyText]
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