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Details on Person ALAD binds to Pb2+

Class:IdReaction:190141
_displayNameALAD binds to Pb2+
_doReleaseTRUE
_timestamp2025-08-13 19:23:26
authored[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity[CatalystActivity:9955860] lead ion binding activity of ALAD [cytosol]
catalystActivityReference[CatalystActivityReference:9955839] lead ion binding activity of ALAD [cytosol] The molecular mechanism of lead inhibition of human porphobilinogen synthase
compartment[Compartment:70101] cytosol
created[InstanceEdit:190162] Jassal, B, 2006-12-18 09:12:35
disease[Disease:5662932] disease
edited[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
input[Complex:189400] 8x(ALAD:Zn2+) [cytosol] [Homo sapiens]
[SimpleEntity:190173] Pb2+ [cytosol]
[SimpleEntity:190173] Pb2+ [cytosol]
[SimpleEntity:190173] Pb2+ [cytosol]
[SimpleEntity:190173] Pb2+ [cytosol]
internalReviewed[InstanceEdit:9961199] D'Eustachio, Peter, 2025-07-21
literatureReference[LiteratureReference:190149] The molecular mechanism of lead inhibition of human porphobilinogen synthase
modified[InstanceEdit:191748] Jassal, B, 2007-01-24 10:21:13
[InstanceEdit:191898] D'Eustachio, P, 2007-01-25 14:05:55
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30
[InstanceEdit:2995335] Jassal, B, 2013-01-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9853729] D'Eustachio, Peter, 2023-11-20
[InstanceEdit:9854167] D'Eustachio, Peter, 2023-11-22
[InstanceEdit:9861358] D'Eustachio, Peter, 2024-02-16
[InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
[InstanceEdit:9961200] D'Eustachio, Peter, 2025-07-21
[InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
nameALAD binds to Pb2+
ALAD octamer associates with Pb++, forming a catalytically inactive complex
output[Complex:190145] 8xALAD:Pb2+:Zn2+ [cytosol] [Homo sapiens]
[SimpleEntity:29426] Zn2+ [cytosol]
[SimpleEntity:29426] Zn2+ [cytosol]
[SimpleEntity:29426] Zn2+ [cytosol]
[SimpleEntity:29426] Zn2+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2007-02-20
reviewed[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
[InstanceEdit:9861359] Hill, David P, 2024-02-16
[InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07
[InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359497] R-HSA-190141.4
structureModified[InstanceEdit:9853729] D'Eustachio, Peter, 2023-11-20
[InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
summation[Summation:190151] Lead binds to ALAD enzyme displacing half the zinc ions esse...
(hasEvent)[Pathway:189451] Heme biosynthesis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788036] Update Tracker - [Reaction:190141] ALAD binds to Pb2+ - v44:[modifyText]
[_UpdateTracker:9964705] Update Tracker - [Reaction:190141] ALAD binds to Pb2+ - v94:[removeCatalystActivity]
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No pathways have been reviewed or authored by ALAD binds to Pb2+ (190141)
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