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Details on Person Activated TrkA receptor internalizes to endosomes

Class:Id	BlackBoxEvent:190065
_displayName	Activated TrkA receptor internalizes to endosomes
_doRelease	TRUE
_timestamp	2024-03-18 20:06:11
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:190076] Jassal, B, 2006-12-14 13:53:55
input	[Complex:166540] Activated TrkA receptor complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:8984943] Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival [LiteratureReference:182096] Nerve growth factor activates persistent Rap1 signaling in endosomes
modified	[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:204710] Gopinathrao, G, 2007-11-29 16:41:43 [InstanceEdit:211746] Jassal, B, 2008-02-08 11:38:28 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:6792861] Jassal, Bijay, 2015-08-28 [InstanceEdit:8984961] Duenas, Corina, 2017-04-11 [InstanceEdit:9610175] Rothfels, Karen, 2018-06-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865777] Orlic-Milacic, Marija, 2024-03-18
name	Activated TrkA receptor internalizes to endosomes
negativePrecedingEvent	[NegativePrecedingEvent:9865770] Futile Cycle: Active PLCG1 dissociates from TrkA receptor [NegativePrecedingEvent:9865760] Futile Cycle: Phospho-Shc dissociates from the TrkA receptor
output	[Complex:190083] Activated TrkA receptor complex [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:166544] TrkA receptor autophosphorylates [Homo sapiens] [Reaction:166538] The bound receptor dimerizes [Homo sapiens]
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359532] R-HSA-190065.6
summation	[Summation:211750] TRKA at the plasma membrane typically results in rapid endoc...
(hasEvent)	[Pathway:187042] TRKA activation by NGF [Homo sapiens]
(precedingEvent)	[Reaction:170964] FRS2 binds to active TrkA receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779051] Update Tracker - [BlackBoxEvent:190065] Activated TrkA receptor internalizes to endosomes - v66:[addLiteratureReference, modifyText] [_UpdateTracker:9781202] Update Tracker - [BlackBoxEvent:190065] Activated TrkA receptor internalizes to endosomes - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9791935] Update Tracker - [BlackBoxEvent:190065] Activated TrkA receptor internalizes to endosomes - v24:[addSummation]
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