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Details on Person ALAS condenses SUCC-CoA and Gly to form dALA

Class:Id	Reaction:189442
_displayName	ALAS condenses SUCC-CoA and Gly to form dALA
_doRelease	TRUE
_timestamp	2023-11-22 20:32:03
authored	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
catalystActivity	[CatalystActivity:189479] 5-aminolevulinate synthase activity of ALAS1,2 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:189470] Jassal, B, 2006-11-20 11:41:56
edited	[InstanceEdit:191749] Jassal, B, D'Eustachio, P, 2007-01-24 10:19:49
input	[SimpleEntity:70958] SUCC-CoA [mitochondrial matrix] [SimpleEntity:159549] Gly [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference	[LiteratureReference:189502] Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man [LiteratureReference:190160] Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans
modified	[InstanceEdit:189506] Jassal, B, 2006-11-22 11:13:09 [InstanceEdit:189973] Jassal, B, 2006-12-13 09:03:56 [InstanceEdit:190162] Jassal, B, 2006-12-18 09:12:35 [InstanceEdit:191748] Jassal, B, 2007-01-24 10:21:13 [InstanceEdit:191898] D'Eustachio, P, 2007-01-25 14:05:55 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30 [InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:2995335] Jassal, B, 2013-01-22 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9640386] D'Eustachio, Peter, 2019-03-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853619] D'Eustachio, Peter, 2023-11-17 [InstanceEdit:9854167] D'Eustachio, Peter, 2023-11-22
name	ALAS condenses SUCC-CoA and Gly to form dALA glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA)
output	[SimpleEntity:189466] dALA [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix]
regulatedBy	[NegativeRegulation:189417] Negative regulation by 'heme [mitochondrial matrix]'
releaseDate	2007-02-20
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361168] R-HSA-189442.5
summation	[Summation:189409] The committed step for porphyrin synthesis is the formation ...
(hasEvent)	[Pathway:189451] Heme biosynthesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:189456] Mitochondrial dALA translocates to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777687] Update Tracker - [Reaction:189442] ALAS condenses SUCC-CoA and Gly to form dALA - v69:[addInput]
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