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Details on Person HMOX1 dimer, HMOX2 cleave heme

Class:IdReaction:189398
_displayNameHMOX1 dimer, HMOX2 cleave heme
_doReleaseTRUE
_timestamp2021-01-29 10:54:51
authored[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
catalystActivity[CatalystActivity:189379] heme oxygenase (decyclizing) activity of HMOX1 dimer, HMOX2 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
edited[InstanceEdit:9707994] Jassal, Bijay, 2020-11-23
input[SimpleEntity:71185] ferroheme [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29368] O2 [cytosol]
modified[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30
[InstanceEdit:589905] D'Eustachio, P, 2010-04-12
[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9706820] Stephan, Ralf, 2020-11-09
[InstanceEdit:9706830] Stephan, Ralf, 2020-11-09
[InstanceEdit:9707994] Jassal, Bijay, 2020-11-23
[InstanceEdit:9713665] Stephan, Ralf, 2021-01-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHMOX1 dimer, HMOX2 cleave heme
The heme ring is cleaved by heme oxygenase
output[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:71067] Fe2+ [cytosol]
[SimpleEntity:189385] CO [cytosol]
[SimpleEntity:189396] BV [cytosol]
precedingEvent
releaseDate2010-06-15
reviewed[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
[InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104382] R-HSA-189398.5
summation[Summation:189394] Heme oxygenases (HMOXs) cleaves the heme ring at the alpha-m...
(hasEvent)[Pathway:189483] Heme degradation [Homo sapiens]
[Pathway:917937] Iron uptake and transport [Homo sapiens]
[Pathway:9707564] Cytoprotection by HMOX1 [Homo sapiens]
(precedingEvent)[Reaction:189384] BLVRA:Zn2+, BLVRB reduce BV to BIL [Homo sapiens]
[BlackBoxEvent:9709366] CO translocates from cytosol to mitochondrial inner membrane [Homo sapiens]
[BlackBoxEvent:9709396] CO translocates from cytosol to extracellular region [Homo sapiens]
[Reaction:9709445] CO binds to soluble guanylate cyclase [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776538] Update Tracker - [Reaction:189398] HMOX1 dimer, HMOX2 cleave heme - v75:[modifyText]
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No pathways have been reviewed or authored by HMOX1 dimer, HMOX2 cleave heme (189398)
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