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Details on Person BLVRA:Zn2+, BLVRB reduce BV to BIL

Class:Id	Reaction:189384
_displayName	BLVRA:Zn2+, BLVRB reduce BV to BIL
_doRelease	TRUE
_timestamp	2021-01-29 10:52:59
authored	[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
catalystActivity	[CatalystActivity:189392] biliverdin reductase [NAD(P)H] activity of BLVRA:Zn2+,BLVRB [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
edited	[InstanceEdit:9661808] Jassal, Bijay, 2019-09-18
input	[SimpleEntity:189396] BV [cytosol] [SimpleEntity:29364] NADPH [cytosol]
literatureReference	[LiteratureReference:9661493] Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXα reductase [LiteratureReference:9661501] Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B)
modified	[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30 [InstanceEdit:589905] D'Eustachio, P, 2010-04-12 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984615] Duenas, Corina, 2017-04-10 [InstanceEdit:9661421] Jassal, Bijay, 2019-09-16 [InstanceEdit:9661519] Jassal, Bijay, 2019-09-17 [InstanceEdit:9661808] Jassal, Bijay, 2019-09-18 [InstanceEdit:9713665] Stephan, Ralf, 2021-01-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BLVRA:Zn2+, BLVRB reduce BV to BIL
output	[SimpleEntity:189386] BIL [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:189398] HMOX1 dimer, HMOX2 cleave heme [Homo sapiens] [Reaction:9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol [Homo sapiens] [BlackBoxEvent:9707645] HMOX1 gene produces HMOX1 dimer [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36 [InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07 [InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105262] R-HSA-189384.6
summation	[Summation:189380] Bilirubin (BIL) is the breakdown product of heme, causing de...
(hasEvent)	[Pathway:189483] Heme degradation [Homo sapiens] [Pathway:9707564] Cytoprotection by HMOX1 [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9955841] BLVRA:Zn2+, BLVRB reduce BV to BIL [NegativePrecedingEvent:9955850] BLVRA:Zn2+, BLVRB reduce BV to BIL [Reaction:9661405] ABCC1 transports BIL from cytosol to extracellular region (blood) [Homo sapiens] [BlackBoxEvent:9709878] BIL translocates to the nucleus [Homo sapiens] [BlackBoxEvent:9709879] BIL scavenges O2.- [Homo sapiens] [Reaction:9709885] BIL scavenges NO [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777456] Update Tracker - [Reaction:189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - v71:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9781236] Update Tracker - [Reaction:189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - v61:[addLiteratureReference]
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No pathways have been reviewed or authored by BLVRA:Zn2+, BLVRB reduce BV to BIL (189384)