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Details on Person BIL translocates from the cytosol to the ER lumen

Class:IdBlackBoxEvent:189381
_displayNameBIL translocates from the cytosol to the ER lumen
_doReleaseTRUE
_timestamp2025-06-11 19:59:48
compartment[Compartment:70101] cytosol
[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:189383] Jassal, Bijay, 2006-11-20
input[SimpleEntity:189386] BIL [cytosol]
literatureReference[LiteratureReference:8984856] [Intracellular bilirubin transport and the membrane of the hepatic endoplasmic reticulum: new aspects in the development of transitory bilirubinemia of the newborn]
[LiteratureReference:9661503] Extensive protein-protein interactions involving UDP-glucuronosyltransferase (UGT) 2B7 in human liver microsomes
modified[InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:421638] D'Eustachio, P, 2009-05-19 13:26:30
[InstanceEdit:589905] D'Eustachio, P, 2010-04-12
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984883] Duenas, Corina, 2017-04-11
[InstanceEdit:9661421] Jassal, Bijay, 2019-09-16
[InstanceEdit:9661519] Jassal, Bijay, 2019-09-17
[InstanceEdit:9661719] Jassal, Bijay, 2019-09-18
[InstanceEdit:9661797] Jassal, Bijay, 2019-09-18
[InstanceEdit:9661808] Jassal, Bijay, 2019-09-18
[InstanceEdit:9663503] Jassal, Bijay, 2019-10-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
nameBIL translocates from the cytosol to the ER lumen
negativePrecedingEvent[NegativePrecedingEvent:9955841] BLVRA:Zn2+, BLVRB reduce BV to BIL
[NegativePrecedingEvent:9955862] SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
[NegativePrecedingEvent:9955856] SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
[NegativePrecedingEvent:9955857] SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)
output[SimpleEntity:159151] BIL [endoplasmic reticulum lumen]
precedingEvent
releaseDate2010-06-15
reviewed[InstanceEdit:191750] Sassa, S, 2007-01-24 10:18:36
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:421639] D'Eustachio, P, 2009-05-19 13:25:07
[InstanceEdit:9661807] Jassal, Bijay, 2019-09-18
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105633] R-HSA-189381.6
summation[Summation:189397] The enzyme which catalyzes the conjugation of bilirubin (UGT...
(hasEvent)[Pathway:189483] Heme degradation [Homo sapiens]
(precedingEvent)[Reaction:159194] UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG [Homo sapiens]
[Reaction:9632039] UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777477] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v71:[addLiteratureReference, modifyText]
[_UpdateTracker:9781457] Update Tracker - [BlackBoxEvent:189381] BIL translocates from the cytosol to the ER lumen - v61:[addLiteratureReference]
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