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Details on Person SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

Class:Id	Reaction:189208
_displayName	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 08:00:43
authored	[InstanceEdit:189111] D'Eustachio, P, 2006-11-03 14:36:07
catalystActivity	[CatalystActivity:428653] D-glucose:sodium symporter activity of SLC5A2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643224] glucose:sodium symporter activity of SLC5A2 [plasma membrane] Renal Na(+)-glucose cotransporters
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:189226] D'Eustachio, P, 2006-11-04 20:44:47
edited	[InstanceEdit:189226] D'Eustachio, P, 2006-11-04 20:44:47
input	[SimpleEntity:70115] Glc [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:429604] Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria [LiteratureReference:189223] Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles [LiteratureReference:429653] SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose [LiteratureReference:8981518] SGLT2 mediates glucose reabsorption in the early proximal tubule [LiteratureReference:8981517] Renal Na(+)-glucose cotransporters
modified	[InstanceEdit:191105] D'Eustachio, P, 2007-01-18 18:40:09 [InstanceEdit:428654] D'Eustachio, P, 2009-07-06 [InstanceEdit:433652] Jassal, Bijay, 2009-08-24 [InstanceEdit:433654] Jassal, Bijay, 2009-08-24 [InstanceEdit:446536] Jassal, Bijay, 2009-11-13 [InstanceEdit:8932953] Jassal, Bijay, 2016-08-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981519] D'Eustachio, Peter, 2017-03-09 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963472] Stephan, Ralf, 2025-08-14
name	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963432] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963452] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
output	[SimpleEntity:70113] Glc [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2006-01-23
reviewed	[InstanceEdit:191112] Wright, EM, 2007-01-15 21:00:45
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361717] R-HSA-189208.7
summation	[Summation:189198] SLC5A2 (also known as SGLT2) in the plasma membrane co-trans...
(hasEvent)	[Pathway:189200] Cellular hexose transport [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963439] Futile Cycle: SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol [NegativePrecedingEvent:9963448] Futile Cycle: SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
(updatedInstance)	[_UpdateTracker:9781482] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v61:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9791436] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v30:[addCatalystActivity, removeRegulator]
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