Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person lactose + H2O => D-glucose + D-galactose

Class:IdReaction:189062
_displayNamelactose + H2O => D-glucose + D-galactose
_doReleaseTRUE
_timestamp2025-09-13 08:10:52
authored[InstanceEdit:189111] D'Eustachio, P, 2006-11-03 14:36:07
catalystActivity[CatalystActivity:188991] lactase activity of LCT dimer [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:189008] D'Eustachio, P, 2006-11-03 14:39:28
crossReference[DatabaseIdentifier:9966224] RHEA:10077
input[SimpleEntity:188973] Lac [extracellular region]
[SimpleEntity:109276] H2O [extracellular region]
literatureReference[LiteratureReference:5675270] Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein
[LiteratureReference:188997] Changing genes; losing lactase
[LiteratureReference:189055] Human lactase-phlorizin hydrolase: evidence of dimerization in the endoplasmic reticulum
[LiteratureReference:188987] Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells
[LiteratureReference:191100] Genetics of lactase persistence and lactose intolerance
[LiteratureReference:189080] Proteolytic processing of human lactase-phlorizin hydrolase is a two-step event: identification of the cleavage sites
modified[InstanceEdit:191105] D'Eustachio, P, 2007-01-18 18:40:09
[InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5658057] D'Eustachio, Peter, 2014-12-16
[InstanceEdit:5675267] D'Eustachio, Peter, 2015-02-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9966227] Stephan, Ralf, 2025-09-13
namelactose + H2O => D-glucose + D-galactose
Digestion of lactose to yield glucose and galactose
output[SimpleEntity:70115] Glc [extracellular region]
[SimpleEntity:188995] Gal [extracellular region]
releaseDate2007-02-20
reviewed[InstanceEdit:191109] Nichols, BL, 2007-01-15 21:51:24
[InstanceEdit:5675273] Naim, Hassan Y, Amiri, Mahdi, 2015-02-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361415] R-HSA-189062.3
summation[Summation:189031] Extracellular lactose is hydrolyzed to yield molecules of gl...
(hasEvent)[Pathway:189085] Digestion of dietary carbohydrate [Homo sapiens]
(normalReaction)[FailedReaction:5658001] Defective LCT does not hydrolyze Lac [Homo sapiens]
(precedingEvent)[Reaction:8932955] SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785069] Update Tracker - [Reaction:189062] lactose + H2O => D-glucose + D-galactose - v52:[addLiteratureReference, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by lactose + H2O => D-glucose + D-galactose (189062)
Follow Reactome