Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Extracellular lactose is hydrolyzed to yield molecules of gl...
| Class:Id | Summation:189031 |
|---|---|
| _displayName | Extracellular lactose is hydrolyzed to yield molecules of gl... |
| _timestamp | 2015-02-15 17:43:43 |
| created | [InstanceEdit:189008] D'Eustachio, P, 2006-11-03 14:39:28 |
| modified | [InstanceEdit:191105] D'Eustachio, P, 2007-01-18 18:40:09 [InstanceEdit:5658057] D'Eustachio, Peter, 2014-12-16 [InstanceEdit:5675267] D'Eustachio, Peter, 2015-02-15 |
| text | Extracellular lactose is hydrolyzed to yield molecules of glucose and galactose, in a reaction catalyzed by the lactase activity of lactase-phlorizin hydrolase associated with the plasma membrane. In the body, lactase-phlorzin hydrolase is found on the external face of enterocytes in microvilli of the small intestine (Hauri et al. 1985). Expression of the enzyme is developmentally regulated and subject to a genetic polymorphism: enzyme levels fall after weaning but the extent of the fall varies sharply between human populations (Grand et al. 2003; Swallow 2003). The lactase-phlorizin hydrolase polypeptide undergoes dimerization and two rounds of proteolytic cleavage in the course of its maturation and transport to the cell surface (Grunberg and Sterchi 1995; Wuthrich et al. 1996; Behrendt et al. 2010). |
| (summation) | [Reaction:189062] lactose + H2O => D-glucose + D-galactose [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Extracellular lactose is hydrolyzed to yield molecules of gl... (189031)
