Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person Cytoplasmic target proteins containing the SH2 domain can bi...
| Class:Id | Summation:188438 |
|---|---|
| _displayName | Cytoplasmic target proteins containing the SH2 domain can bi... |
| _timestamp | 2023-01-22 19:20:47 |
| created | [InstanceEdit:188436] Jassal, B, 2006-10-13 13:48:32 |
| modified | [InstanceEdit:189934] Jassal, Bijay, 2006-12-08 [InstanceEdit:9824816] Orlic-Milacic, Marija, 2023-01-22 |
| text | Cytoplasmic target proteins containing the SH2 domain can bind to activated EGFR. One such protein, growth factor receptor-bound protein 2 (GRB2), can bind activated EGFR with its SH2 domain whilst in complex with SOS through its SH3 domain. GRB2 can bind at either Y1092 i.e. Y1068 in the mature protein and/or Y1110 i.e. Y1086 in the mature protein tyrosine autophosphorylation sites on the receptor. |
| (summation) | [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens] [Reaction:9846377] GOCAM GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens] |
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No pathways have been reviewed or authored by Cytoplasmic target proteins containing the SH2 domain can bi... (188438)
