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Details on Person Association of Rb with Cyclin E:Cdk2 complexes

Class:Id	Reaction:188386
_displayName	Association of Rb with Cyclin E:Cdk2 complexes
_doRelease	TRUE
_timestamp	2022-02-08 21:28:12
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:188385] Matthews, L, 2006-10-10 13:59:32
edited	[InstanceEdit:188346] Matthews, L, 2006-10-10 08:05:07
input	[Complex:188362] Cyclin E:p-T160-CDK2 [nucleoplasm] [Homo sapiens] [DefinedSet:9687348] monophosphorylated RB1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:188366] Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein [LiteratureReference:188351] Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes
modified	[InstanceEdit:188499] Matthews, L, 2006-10-16 20:29:18 [InstanceEdit:617356] Matthews, L, 2010-04-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9687375] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9687376] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9764006] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of Rb with Cyclin E:Cdk2 complexes
negativePrecedingEvent	[NegativePrecedingEvent:9763997] Futile Cycle: Cyclin E:CDK2-mediated phosphorylation of RB1 [NegativePrecedingEvent:9763992] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
output	[Complex:188373] CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 [Homo sapiens] [BlackBoxEvent:187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome [Homo sapiens] [Reaction:157906] Translocation of Cyclin E:Cdk2 complex to the nucleus [Homo sapiens] [Reaction:69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 [Homo sapiens] [BlackBoxEvent:9659820] RB1 translocates to the nucleus [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361416] R-HSA-188386.5
summation	[Summation:188384] pRB contains, in its C terminus, a cyclin-cdk interaction mo...
(hasEvent)	[Pathway:69202] Cyclin E associated events during G1/S transition [Homo sapiens]
(precedingEvent)	[Reaction:188390] Cyclin E:CDK2-mediated phosphorylation of RB1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777004] Update Tracker - [Reaction:188386] Association of Rb with Cyclin E:Cdk2 complexes - v73:[add_removeInput]
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No pathways have been reviewed or authored by Association of Rb with Cyclin E:Cdk2 complexes (188386)