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Details on Person The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex

Class:Id	BlackBoxEvent:188345
_displayName	The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
_doRelease	TRUE
_timestamp	2017-02-17 14:21:13
authored	[InstanceEdit:187972] Matthews, L, 2006-09-29 13:59:34
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:188343] Matthews, L, 2006-10-10 13:52:41
edited	[InstanceEdit:188346] Matthews, L, 2006-10-10 08:05:07
input	[EntityWithAccessionedSequence:4088168] CDC25A gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:188344] Cdc25 cell-cycle phosphatase as a target of c-myc [LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:141377] CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase [LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
modified	[InstanceEdit:188495] Matthews, L, 2006-10-16 20:24:40 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:2836587] Orlic-Milacic, M, 2012-12-11 [InstanceEdit:8932404] Orlic-Milacic, Marija, 2016-07-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8961966] Orlic-Milacic, Marija, 2017-02-06 [InstanceEdit:8964506] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:8964528] Orlic-Milacic, Marija, 2017-02-17 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
output	[EntityWithAccessionedSequence:143487] CDC25A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8932400] MYC:MAX binds the CDC25A gene [Homo sapiens] [BlackBoxEvent:1980067] NOTCH1 stimulates MYC transcription [Homo sapiens] [BlackBoxEvent:4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene [Homo sapiens] [BlackBoxEvent:1484099] MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex [Homo sapiens] [Reaction:8961961] E2F1 binds the CDC25A gene promoter [Homo sapiens] [Reaction:69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes [Homo sapiens] [Reaction:8964471] DREAM complex binds the CDC25A gene promoter [Homo sapiens] [Reaction:1362261] p130 (RBL2) associates with MuvB to form DREAM complex [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:188376] Positive gene expression regulation by 'MYC:MAX:CDC25A gene [nucleoplasm]' [PositiveGeneExpressionRegulation:8961967] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm]' [NegativeGeneExpressionRegulation:8964503] Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]'
regulationReference	[RegulationReference:9642317] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [RegulationReference:9642802] Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2006-04-24
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06 [InstanceEdit:1538129] MacPherson, D, 2011-08-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359301] R-HSA-188345.7
summation	[Summation:188348] Binding of the MYC:MAX heterodimer to MYC response elements ...
(hasEvent)	[Pathway:69202] Cyclin E associated events during G1/S transition [Homo sapiens] [Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry [Homo sapiens] [Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex [Homo sapiens]
(precedingEvent)	[Reaction:69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A [Homo sapiens] [Reaction:170158] CDC25A dephosphorylates CCNA:CDK1 [Homo sapiens] [Reaction:174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781771] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v60:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9783000] Update Tracker - [BlackBoxEvent:188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - v58:[addInput, add_removeRegulator, modifyText]
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