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Details on Person APC/C:Cdh1-mediated degradation of Skp2

Class:Id	BlackBoxEvent:188191
_displayName	APC/C:Cdh1-mediated degradation of Skp2
_doRelease	TRUE
_timestamp	2022-09-13 18:03:52
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:188186] Matthews, L, 2006-10-02 06:21:46
edited	[InstanceEdit:188189] Matthews, L, 2006-10-01 21:26:42 [InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
figure	[Figure:188187] /figures/Skp2_degradation.jpg
input	[Complex:188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:187864] Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex [LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
modified	[InstanceEdit:188494] Matthews, L, 2006-10-16 20:22:58 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:613446] Matthews, L, 2010-04-19 [InstanceEdit:1222253] Matthews, L, 2011-02-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9686984] Orlic-Milacic, Marija, 2020-05-05 [InstanceEdit:9687090] Orlic-Milacic, Marija, 2020-05-06 [InstanceEdit:9687398] Orlic-Milacic, Marija, 2020-05-07 [InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18 [InstanceEdit:9816782] Orlic-Milacic, Marija, 2022-09-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	APC/C:Cdh1-mediated degradation of Skp2
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens] [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9686969] APC/C:Cdh1 polyubiquitinates SKP2 [Homo sapiens] [Reaction:9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09 [InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361955] R-HSA-188191.5
summation	[Summation:188188] SKP2 is degraded by the anaphase promoting complex/Cyclosome...
(hasEvent)	[Pathway:174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764079] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764082] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764119] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764120] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2
(updatedInstance)	[_UpdateTracker:9777056] Update Tracker - [BlackBoxEvent:188191] APC/C:Cdh1-mediated degradation of Skp2 - v73:[addLiteratureReference, add_removeCatalystActivity, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by APC/C:Cdh1-mediated degradation of Skp2 (188191)