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Details on Person UniProt:Q9NYK1 TLR7
| Class:Id | ReferenceGeneProduct:188133 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1049 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NYK1 TLR7 |
| _timestamp | 2025-02-21 19:33:57 |
| chain | signal peptide:1-26 chain:27-1049 |
| checksum | 8C701E9E437F2721 |
| comment | FUNCTION Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:12738885, PubMed:27742543, PubMed:31608988, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state.ACTIVITY REGULATION Activated by guanosine analogs including deoxyguanosine, 7-thia-8-oxoguanosine or 7-deazaguanosine in a RNA-independent manner. Activated by imiquimod (PubMed:32706371).SUBUNIT Homodimer (PubMed:27742543). Interacts with MYD88 via their respective TIR domains (Probable). Interacts with UNC93B1 (PubMed:33432245). Interacts with SMPDL3B (By similarity).SUBCELLULAR LOCATION Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.TISSUE SPECIFICITY Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Expressed in peripheral mononuclear blood cells (PubMed:32706371).DOMAIN Contains two binding domains, first site for small ligands and second site for ssRNA.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the Toll-like receptor family. |
| created | [InstanceEdit:188134] de Bono, B, 2006-09-30 14:23:28 |
| description | recommendedName: fullName evidence="14"Toll-like receptor 7 |
| geneName | TLR7 UNQ248/PRO285 |
| identifier | Q9NYK1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasmic vesicle Disease variant Endoplasmic reticulum Endosome Glycoprotein Immunity Inflammatory response Innate immunity Leucine-rich repeat Lysosome Membrane Proteomics identification Receptor Reference proteome Repeat Signal Systemic lupus erythematosus Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TLR7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001497] ENSEMBL:ENSG00000196664 TLR7 [Homo sapiens] |
| secondaryIdentifier | TLR7_HUMAN D1CS69 Q9NR98 |
| sequenceLength | 1049 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:168005] TLR7 [endolysosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:1678929] TLR7 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:1678943] TLR7 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:1679027] TLR7(?-1049) [endolysosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:1679579] TLR7(?-1049) [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:9678802] TLR7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9824828] TLR7(?-1049) Y264H [endolysosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:9824848] TLR7(?-1049) F507L [endolysosome membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:9824824] L-tyrosine 264 replaced with L-histidine [ReplacedResidue:9824850] L-phenylalanine 507 replaced with L-leucine |
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No pathways have been reviewed or authored by UniProt:Q9NYK1 TLR7 (188133)
