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Details on Person Rab5-mediated recruitment of class III PI3K to TLR9

Class:Id	Reaction:188002
_displayName	Rab5-mediated recruitment of class III PI3K to TLR9
_doRelease	TRUE
_timestamp	2016-11-10 00:57:19
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:188003] de Bono, B, 2006-09-29 15:22:42
input	[Complex:188015] PI3K class III [cytosol] [Homo sapiens] [Complex:1679087] C-ter TLR9 dimer:unmethylated CpG DNA [endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:187889] Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9 [LiteratureReference:2445189] TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway
modified	[InstanceEdit:188004] de Bono, B, 2006-09-29 15:24:34 [InstanceEdit:188016] de Bono, B, 2006-09-29 15:41:39 [InstanceEdit:188024] de Bono, B, 2006-09-29 15:53:38 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188666] de Bono, B, 2006-10-20 12:06:04 [InstanceEdit:188741] de Bono, B, 2006-10-27 09:31:42 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1679139] Shamovsky, V, 2011-10-19 [InstanceEdit:1679583] Shamovsky, V, 2011-10-20 [InstanceEdit:2445244] Shamovsky, V, 2012-08-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Rab5-mediated recruitment of class III PI3K to TLR9
output	[Complex:188017] activated TLR9:PI3K class III [cytosol] [Homo sapiens]
precedingEvent	[Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 [Homo sapiens] [Reaction:1678920] TLR processing at low pH [Homo sapiens]
regulatedBy	[Requirement:188013] Requirement by 'ZFYVE20 [endosome membrane]'
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361819] R-HSA-188002.4
summation	[Summation:188740] TLR9 signaling has the uncommon property of triggering PI3K-...
(hasEvent)	[Pathway:168138] Toll Like Receptor 9 (TLR9) Cascade [Homo sapiens]
(precedingEvent)	[Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788345] Update Tracker - [Reaction:188002] Rab5-mediated recruitment of class III PI3K to TLR9 - v42:[addLiteratureReference] [_UpdateTracker:9789043] Update Tracker - [Reaction:188002] Rab5-mediated recruitment of class III PI3K to TLR9 - v39:[add_removeInput]
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