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Details on Person Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2

Class:Id	Reaction:187948
_displayName	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
_doRelease	TRUE
_timestamp	2022-02-08 21:34:58
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:6805116] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:187964] Matthews, L, 2006-09-29 13:54:26
edited	[InstanceEdit:187878] Matthews, L, 2006-09-28 04:25:14
input	[DefinedSet:187963] FZR1,p-S795-RB1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:187958] Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes [LiteratureReference:187515] Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation [LiteratureReference:187523] p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 [LiteratureReference:187945] Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
modified	[InstanceEdit:188396] Matthews, L, 2006-10-10 14:02:23 [InstanceEdit:188484] Matthews, L, 2006-10-16 06:16:25 [InstanceEdit:188516] Matthews, L, 2006-10-17 04:39:39 [InstanceEdit:188690] Matthews, L, 2006-10-24 04:21:01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9032187] Orlic-Milacic, Marija, 2017-12-07 [InstanceEdit:9764012] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
negativePrecedingEvent	[NegativePrecedingEvent:9764007] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
output	[DefinedSet:187920] p-FZR1,p-RB1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 [Homo sapiens] [Reaction:174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 [Homo sapiens] [BlackBoxEvent:187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome [Homo sapiens] [Reaction:174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus [Homo sapiens]
releaseDate	2006-11-16
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359363] R-HSA-187948.5
summation	[Summation:187935] Active Cyclin A:Cdk2 complexes phosphorylate and inactivate ...
(hasEvent)	[Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780080] Update Tracker - [Reaction:187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - v64:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9788823] Update Tracker - [Reaction:187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - v40:[modifyText]
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