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Details on Person Inactivation of Cyclin A:Cdk2 complexes by p27/p21

Class:Id	Reaction:187934
_displayName	Inactivation of Cyclin A:Cdk2 complexes by p27/p21
_doRelease	TRUE
_timestamp	2022-02-08 21:34:54
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:188223] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:187964] Matthews, L, 2006-09-29 13:54:26
edited	[InstanceEdit:187878] Matthews, L, 2006-09-28 04:25:14
input	[Complex:141608] CCNA:CDK2 [nucleoplasm] [Homo sapiens] [DefinedSet:182558] CDKN1A,CDKN1B [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:187515] Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation [LiteratureReference:69417] The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
modified	[InstanceEdit:188227] Matthews, L, 2006-10-03 13:09:01 [InstanceEdit:188395] Matthews, L, 2006-10-10 14:00:29 [InstanceEdit:188513] Matthews, L, 2006-10-17 04:38:52 [InstanceEdit:3788635] Orlic-Milacic, M, 2013-07-04 [InstanceEdit:3828044] Orlic-Milacic, M, 2013-07-09 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810450] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856094] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8862042] Orlic-Milacic, Marija, 2016-02-24 [InstanceEdit:8871595] Orlic-Milacic, Marija, 2016-05-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9032207] Orlic-Milacic, Marija, 2017-12-07 [InstanceEdit:9645173] Orlic-Milacic, Marija, 2019-05-06 [InstanceEdit:9764012] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inactivation of Cyclin A:Cdk2 complexes by p27/p21
negativePrecedingEvent	[NegativePrecedingEvent:9764009] Futile Cycle: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
output	[Complex:187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:187828] Translocation of p21 to the nucleus [Homo sapiens] [Reaction:187506] Translocation of p27 to the nucleoplasm [Homo sapiens] [Reaction:174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus [Homo sapiens] [Reaction:174054] Formation of Cyclin A:Cdk2 complexes [Homo sapiens] [BlackBoxEvent:6803411] PCBP4 modulates CDKN1A translation [Homo sapiens] [Reaction:6803403] PCBP4 binds the CDKN1A mRNA [Homo sapiens] [BlackBoxEvent:6803388] TP53 stimulates CDKN1A (p21) transcription [Homo sapiens] [BlackBoxEvent:4647613] Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 [Homo sapiens] [Reaction:3786258] TP53 binds the CDKN1A promoter [Homo sapiens] [Reaction:4647593] EP400 binds CDKN1A promoter [Homo sapiens]
releaseDate	2006-11-16
releaseStatus	UPDATED
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361895] R-HSA-187934.9
summation	[Summation:187936] During G1, the activity of cyclin-dependent kinases (CDKs) i...
(hasEvent)	[Pathway:69563] p53-Dependent G1 DNA Damage Response [Homo sapiens] [Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry [Homo sapiens] [Pathway:2559586] DNA Damage/Telomere Stress Induced Senescence [Homo sapiens] [Pathway:6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Homo sapiens]
(precedingEvent)	[Reaction:187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 [Homo sapiens] [Reaction:187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 [Homo sapiens] [Reaction:3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777765] Update Tracker - [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - v69:[addCatalystActivity] [_UpdateTracker:9780154] Update Tracker - [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - v64:[removeCatalystActivity] [_UpdateTracker:9783499] Update Tracker - [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - v56:[modifyText] [_UpdateTracker:9787121] Update Tracker - [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - v46:[addLiteratureReference]
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