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Details on Person XYLTs transfer Xyl to core protein

Class:Id	Reaction:1878002
_displayName	XYLTs transfer Xyl to core protein
_doRelease	TRUE
_timestamp	2025-03-12 10:05:38
authored	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
catalystActivity	[CatalystActivity:1877999] protein xylosyltransferase activity of XYLT1, XYLT2 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
crossReference	[DatabaseIdentifier:9941498] RHEA:50193
edited	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
input	[SimpleEntity:742361] UDP-Xyl [Golgi lumen] [DefinedSet:2054107] GAG core proteins [Golgi lumen] [Homo sapiens]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:1878004] Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity [LiteratureReference:1878003] Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity [LiteratureReference:1889964] Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II [LiteratureReference:8863597] XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity
modified	[InstanceEdit:1889961] Jassal, B, 2011-11-01 [InstanceEdit:1890000] Jassal, B, 2011-11-01 [InstanceEdit:2054102] Jassal, B, 2012-01-13 [InstanceEdit:2063989] Jassal, B, 2012-01-18 [InstanceEdit:2161486] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:3560781] Jassal, B, 2013-05-21 [InstanceEdit:8863595] Jupe, Steve, 2016-03-09 [InstanceEdit:8931844] Jassal, Bijay, 2016-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9923955] D'Eustachio, Peter, 2024-10-04 [InstanceEdit:9941497] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12
name	XYLTs transfer Xyl to core protein Xylose is transferred to a serine residue on the core protein
output	[SimpleEntity:205687] UDP [Golgi lumen] [DefinedSet:2064201] xylosyl-core proteins [Golgi lumen] [Homo sapiens] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:742373] SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen [Homo sapiens] [Reaction:8863761] UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose [Homo sapiens] [Reaction:9912889] SLC35D2 exchanges UDP-GlcA for UMP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294855] R-HSA-1878002.6
structureModified	[InstanceEdit:9941497] Stephan, Ralf, 2025-03-07
summation	[Summation:1877989] Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step...
(hasEvent)	[Pathway:1971475] Glycosaminoglycan-protein linkage region biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:1889981] B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783027] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v57:[addLiteratureReference, modifyText] [_UpdateTracker:9953643] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v93:[modifyText, removeOutput]
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No pathways have been reviewed or authored by XYLTs transfer Xyl to core protein (1878002)