Query author contributions in Reactome
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Details on Person During G1, the activity of cyclin-dependent kinases (CDKs) i...
| Class:Id | Summation:187795 |
|---|---|
| _displayName | During G1, the activity of cyclin-dependent kinases (CDKs) i... |
| _timestamp | 2016-02-08 20:46:25 |
| created | [InstanceEdit:187794] Matthews, L, 2006-09-28 02:28:29 |
| literatureReference | [LiteratureReference:187842] Stabilizers and destabilizers controlling cell cycle oscillators |
| modified | [InstanceEdit:187975] Matthews, L, 2006-09-29 14:00:16 [InstanceEdit:8856094] Orlic-Milacic, Marija, 2016-02-08 |
| text | During G1, the activity of cyclin-dependent kinases (CDKs) is controlled by the CDK inhibitors (CKIs) CDKN1A (p21) and CDKN1B (p27), thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). The efficient recognition and ubiquitination of p27 by the SCF (Skp2) complex requires the formation of a trimeric complex containing p27 and cyclin E/A:Cdk2. |
| (summation) | [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by During G1, the activity of cyclin-dependent kinases (CDKs) i... (187795)
