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Details on Person Ubiquitination of phospho-p27/p21

Class:Id	Reaction:187575
_displayName	Ubiquitination of phospho-p27/p21
_doRelease	TRUE
_timestamp	2022-02-08 21:28:41
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:187571] ubiquitin-protein transferase activity of Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:187573] Matthews, L, 2006-09-20 13:07:03
edited	[InstanceEdit:187502] Matthews, L, 2006-09-19 08:32:00
input	[Complex:187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:187544] The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27
modified	[InstanceEdit:187870] Matthews, L, 2006-09-28 02:41:51 [InstanceEdit:188400] Matthews, L, 2006-10-10 14:58:22 [InstanceEdit:188523] Matthews, L, 2006-10-17 05:04:49 [InstanceEdit:188945] Gopinathrao, G, 2006-10-31 10:19:12 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:9764006] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitination of phospho-p27/p21
negativePrecedingEvent	[NegativePrecedingEvent:9764003] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
output	[Complex:187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex [Homo sapiens] [Reaction:187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 [Homo sapiens] [Reaction:187545] Association of Cks1 with SCF(Skp2) complex [Homo sapiens]
releaseDate	2006-11-14
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362084] R-HSA-187575.3
summation	[Summation:187570] Once in tight contact with the SCF (Skp2):Cks1 complex, phos...
(hasEvent)	[Pathway:187577] SCF(Skp2)-mediated degradation of p27/p21 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome [Homo sapiens]
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No pathways have been reviewed or authored by Ubiquitination of phospho-p27/p21 (187575)