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Details on Person Degradation of ubiquitinated p27/p21 by the 26S proteasome

Class:IdBlackBoxEvent:187574
_displayNameDegradation of ubiquitinated p27/p21 by the 26S proteasome
_doReleaseTRUE
_timestamp2017-12-07 15:18:02
authored[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:187573] Matthews, L, 2006-09-20 13:07:03
edited[InstanceEdit:187502] Matthews, L, 2006-09-19 08:32:00
input[Complex:187568] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:187517] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
[LiteratureReference:187523] p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27
modified[InstanceEdit:187866] Matthews, L, 2006-09-28 02:39:56
[InstanceEdit:187973] Matthews, L, 2006-09-29 13:59:49
[InstanceEdit:188382] Matthews, L, 2006-10-10 13:58:03
[InstanceEdit:188511] Matthews, L, 2006-10-17 04:38:29
[InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13
[InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:9032207] Orlic-Milacic, Marija, 2017-12-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDegradation of ubiquitinated p27/p21 by the 26S proteasome
output[Complex:187547] CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [Homo sapiens]
[DefinedSet:8848491] CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2006-11-14
reviewed[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358530] R-HSA-187574.3
summation[Summation:187572] Following ubiquitination by the SCF(Skp2):Cks1 complex, phos...
(hasEvent)[Pathway:187577] SCF(Skp2)-mediated degradation of p27/p21 [Homo sapiens]
(precedingEvent)[Reaction:187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 [Homo sapiens]
[Reaction:188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 [Homo sapiens]
[NegativePrecedingEvent:9763992] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
[NegativePrecedingEvent:9763998] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
[NegativePrecedingEvent:9764000] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
[NegativePrecedingEvent:9764003] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
[NegativePrecedingEvent:9764005] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
[NegativePrecedingEvent:9764007] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome
(updatedInstance)[_UpdateTracker:9779874] Update Tracker - [BlackBoxEvent:187574] Degradation of ubiquitinated p27/p21 by the 26S proteasome - v64:[add_removeOutput]
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