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Details on Person Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

Class:Id	Reaction:187552
_displayName	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
_doRelease	TRUE
_timestamp	2022-02-08 21:28:14
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:187561] Matthews, L, 2006-09-20 13:03:43
edited	[InstanceEdit:187502] Matthews, L, 2006-09-19 08:32:00
input	[Complex:187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] [Homo sapiens] [Complex:187547] CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:187544] The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 [LiteratureReference:187523] p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 [LiteratureReference:187566] Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase [LiteratureReference:187564] Noncatalytic requirement for cyclin A-cdk2 in p27 turnover
modified	[InstanceEdit:187808] Matthews, L, 2006-09-28 02:32:05 [InstanceEdit:188315] Matthews, L, 2006-10-06 10:24:18 [InstanceEdit:188501] Matthews, L, 2006-10-16 20:30:47 [InstanceEdit:188944] Gopinathrao, G, 2006-10-31 10:11:13 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:3006449] Jassal, B, 2013-01-30 [InstanceEdit:9764006] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
negativePrecedingEvent	[NegativePrecedingEvent:9764000] Futile Cycle: Degradation of ubiquitinated p27/p21 by the 26S proteasome [NegativePrecedingEvent:9764004] Futile Cycle: Ubiquitination of p130 (RBL2) by SCF (Skp2)
output	[Complex:187565] Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 [Homo sapiens] [Reaction:187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Homo sapiens] [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 [Homo sapiens] [Reaction:187545] Association of Cks1 with SCF(Skp2) complex [Homo sapiens]
releaseDate	2006-11-14
requiredInputComponent	[EntityWithAccessionedSequence:187525] p-T187-CDKN1B [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:975554] SKP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:187533] CKS1B [nucleoplasm] [Homo sapiens]
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359836] R-HSA-187552.3
summation	[Summation:187557] The association of Cks1 with both Skp2 and phosphorylated p2...
(hasEvent)	[Pathway:187577] SCF(Skp2)-mediated degradation of p27/p21 [Homo sapiens]
(precedingEvent)	[Reaction:187575] Ubiquitination of phospho-p27/p21 [Homo sapiens]
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No pathways have been reviewed or authored by Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (187552)