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Details on Person GRB2 is an adaptor molecule containing one SH2 domain and tw...
| Class:Id | Summation:186828 |
|---|---|
| _displayName | GRB2 is an adaptor molecule containing one SH2 domain and tw... |
| _timestamp | 2020-01-13 19:57:25 |
| created | [InstanceEdit:186838] Jassal, B, 2006-08-24 13:02:57 |
| literatureReference | [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors |
| modified | [InstanceEdit:382620] Garapati, P V, 2008-11-24 00:30:36 [InstanceEdit:398078] Garapati, P V, 2009-03-16 14:41:50 [InstanceEdit:9674505] Rothfels, Karen, 2020-01-13 |
| text | GRB2 is an adaptor molecule containing one SH2 domain and two SH3 domains. The SH2 domain of GRB2 binds directly to autophosphorylated PDGF receptors and with its SH3 domain it forms a complex with SOS1. The binding of GRB2:SOS1 to the PDGF receptor juxtaposes the complex towards RAS molecules leading to RAS activation. RAS activates the MAP kinase cascade, a pathway implicated in cell growth stimulation, migration and differentiation. |
| (summation) | [Pathway:186812] Grb2/Sos1 events [Homo sapiens] [Reaction:186826] GRB2:SOS1 complex binds to the active receptor [Homo sapiens] |
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No pathways have been reviewed or authored by GRB2 is an adaptor molecule containing one SH2 domain and tw... (186828)
