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Details on Person GAP binds to PDGF-beta receptors only

Class:Id	Reaction:186798
_displayName	GAP binds to PDGF-beta receptors only
_doRelease	TRUE
_timestamp	2017-12-04 17:01:53
authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:186802] Jassal, B, 2006-08-15 13:51:10
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
input	[EntityWithAccessionedSequence:186833] RASA1 [cytosol] [Homo sapiens] [Complex:389074] Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:381873] GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit [LiteratureReference:382041] Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo [LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors
modified	[InstanceEdit:186838] Jassal, B, 2006-08-24 13:02:57 [InstanceEdit:380784] Garapati, P V, 2008-11-14 10:49:11 [InstanceEdit:382063] Garapati, P V, 2008-11-21 20:22:15 [InstanceEdit:382620] Garapati, P V, 2008-11-24 00:30:36 [InstanceEdit:382628] Garapati, P V, 2008-11-24 10:23:08 [InstanceEdit:389087] Garapati, P V, 2008-12-19 10:29:26 [InstanceEdit:392248] Garapati, P V, 2009-03-01 16:05:31 [InstanceEdit:398091] Garapati, P V, 2009-03-16 16:42:15 [InstanceEdit:469650] Garapati, P V, 2010-01-25 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9031951] Orlic-Milacic, Marija, 2017-12-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAP binds to PDGF-beta receptors only
output	[Complex:186830] Phospho-beta receptor homodimer:GAP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:186786] Autophosphorylation of PDGF beta receptors [Homo sapiens] [BlackBoxEvent:186773] PDGF dimer binds two receptors simultaneously [Homo sapiens]
releaseDate	2009-04-01
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:398379] R-HSA-186798.3
summation	[Summation:186829] GTPase-activating protein (GAP) has two SH2 domains which bi...
(hasEvent)	[Pathway:186763] Downstream signal transduction [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790869] Update Tracker - [Reaction:186798] GAP binds to PDGF-beta receptors only - v32:[add_removeInput]
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